Foreign Perspectives

Things kicked off much quicker this morning as we’d already checked all the glassware yesterday and we’d a better handle on where things were and what to do with them.

Starting with the carboethoxymethylenetriphenylposphorane that we’d made yesterday the plan was to prepare our alkene using ethanol as our reagent (the others starting from the same product used different reagents). There would have been more time between steps today but we were performing a direct synthesis and one using competing reagents so the second synthesis filled the gaps in the first which made for a very full day.

Reaching the end of this stage of the synthesis meant that it was time to analyse the end product using NMR spectroscopy, Infrared spectroscopy and gas chromatography. In practical terms, few people managed to complete the analyses as the various tests weren’t run until quite late in the afternoon so there wasn’t much time to do the analysis before we had to hand in our lab notebooks for assessment. Yup, on this course they actually do check your lab notebooks. This first assessment doesn’t count towards the final mark though and it’s intended to give us pointers as to how to do better when we’re writing up the second lab notebook which does count towards the final exam.

Tonights tutorial discussed our overall results as we’ll need to know how best to make a double bond that’s either E or Z. Also, we’d to pick which of the three substances we’d like to have a go at preparing (queen substance, farnesol and an insect pheromone). We’re going for the pheromone basically because loads of people started off choosing the  queen substance and farnesol is covered in some detail in the pre-course notes already.

Catering-wise, the lunch lets things down and the breakfast and dinner are excellent.

The day got off to a relatively slow start as it took quite a while to check that we’d all the various items of glassware on the checklist and that they were clean.

Our first experiment was to prepare carboethoxymethylenetriphenylposphorane from carboethoxymethyltriphenylphosphonium bromide. That requires a fair number of steps and helps a lot in getting back into the swing of practical chemistry with steps ranging from the simple dissolving of various chemicals, handling assorted chemicals that are toxic, irritants, flammable or indeed all of the above, separating out two different layers of chemicals, evaporating to get rid of solvents and finally weighing what you’ve made to see how efficient your methods were. Along the way, we picked up where the various solvents and reagents were in the lab, built increasingly fancy structures with the clamps, wrote it all down in a lab notebook and finished up with an overall yield of 87% which is pretty amazing. Since we weren’t fully up to speed that ended up taking most of the day and was quite a busy one.

All of us doing the stabilised Wittig procedure followed the above starting approach but we broke up into about half a dozen separate teams later in the afternoon as we used a variety of different reagents to make our alkene.

Catering-wise, the breakfast was excellent with a full English breakfast cooked quite nicely. Lunch was a bit of a let-down as it’s just sandwiches with tea/coffee. The evening lectures were optional with one on interpreting NMR spectra and the other on retro-synthetic analysis (which went way too quickly over the material for me so it’s just as well that the notes will be on the forum in due course).

With registration not starting ’til 2pm, I’d a very slow start to the morning and even managed to make a small start on the SXR376 ECA which I’m hoping to get working on a little bit during the week.

Breakfast is a properly professional affair here and Nottingham isn’t anywhere close to being in the same league for catering generally if today is anything to go by. The accommodation is equally a massive improvement with ensuite rooms and what seems like fairly new furniture too.

The first lecture wasn’t until 4.30pm and was split between the general introductory stuff, a broad overview of the week and a first look at the labs that we’ll be working in. Typically for chemistry, there seemed to be an awful lot of glassware and loads of bottles of reagents.

Dinner was a world away from Nottingham’s effort. We were even told that the chef would like us to be down at 6pm so that his food would be at its best! Maybe it’s more that he’d like to get away early but the impression is that he actually meant what he said, definitely a nice change.

The evening lecture at 7.30pm ran, very briefly, over the assessment before moving on to more detail about what we’ll actually be doing. We won’t get the ECA until August 2nd which I’m not too keen on as I like to have a look at what I’m aiming for so I’ll see if I can have a chat to some people who’ve done chemistry schools before to get at least a feel for it.

The second section of the lecture took a massive lurch into serious chemistry and it was only towards the end of it that I started to get my brain into “chemistry mode”. We’d to volunteer to take on board one of three reactions (stabilised Wittig, non-stabilised Wittig and HWE) with the 20-odd teams of two looking into a different reaction under each group.

Aside from not getting the ECA until well after we’ve left, the other differences from the biology schools that I’ve noticed so far are that the lab coats are supplied here whilst the lab notebooks aren’t so I’ve to acquire two of them tomorrow morning.

With several groups working well into the evening yesterday, the conclusions team was probably not the best team to be on.

Some last minute discussions on our immunocytochemistry presentation resulted in a few updates to what we said but, for a change, no last minute changes to the text of the presentation itself. Unlike last year, we all had at least some knowledge of the various topics being presented which made for a more interesting feel to the morning I think. Once they were completed, we even had some feedback on how well we’d done or rather on some improvements that we might make for the next time.

And then it was time to go our separate ways.

It took a little longer than expected to reach the train station but I’d still got loads of time to wait around. The first class ticket was definitely worthwhile and the meal broke up the journey quite nicely. As it turned out, it was just as well that I took it as there was nothing open on campus by the time I arrived.

Although, at first glance there seem to be cafés and restaurants everywhere on the York campus, outside term-time the opening hours are rather limited. On Friday night there’s only one open and it closes at 7pm. The supermarket in the market square is open Monday to Friday 9am to 5.30pm with the little shop beside it only open from 9am to 2pm Saturday and 9am to 1pm Sunday.

In principle, the remaining lab work looked like it would only take an hour or so but in practice the final washes and particularly getting the slides mounted took ages and we didn’t complete our photography of them until lunchtime.

That in turn meant that we were running rather later than expected in starting the preparation of our presentation for tomorrow. So late that we have one final image to be inserted and we’ve not yet had a full run-through. Mind you, we are the penultimate presentation so we may have time to polish it up a little more before we’re on (although probably not if last year is any guide).

Anyway, that’s the lab work done for this course and we’ve only to do our 10 minute presentation tomorrow before we all go our separate ways. Well, not quite all as a fairly large number of people seem to be doing two residentials this year.

It’s off to see about reading up on my section of the presentation now (short, but with lots of potential for questions).